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Antibiotic resistance in gonorrhea

Resistance to penicillin has developed through two mechanisms: chromasomally mediated resistance CMRNG and penicillinase-mediated resistance PPNG . CMRNG involves step wise mutation of penA, which codes for the penicillin-binding protein PBP-2 ; mtr, which encodes an efflux pump that removes penicillin from the cell; and penB, which encodes the bacterial cell wall porins .

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Antimicrobial resistance

ResistanceOpen is an online global map of antimicrobial resistance developed by HealthMap which displays aggregated data on antimicrobial resistance from publicly available and user submitted data. The website can display data for a 25-mile radius from a location. Users may submit data from antibiograms for individual hospitals or laboratories.

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Gonorrhea

Cases of resistance to ceftriaxone have been reported but are still rare, though public health officials are concerned that an emerging pattern of resistance may predict a global epidemic. The UK& 39;s Health Protection Agency reported that 2011 saw a slight drop in gonorrhea antibiotic resistance, the first in five years.

Enterococcus gallinarum

Enterococcus gallinarum is a species of Enterococcus. E. gallinarum demonstrates an inherent, low-level resistance to vancomycin.Resistance is due to a chromosomal gene, vanC, which encodes for a terminal D-alanine-D-serine instead of the usual D-alanine-D-alanine in cell wall peptidoglycan precursor proteins.

ESKAPE

Common mechanisms for resistance include the production of enzymes that attack the structure of antibiotics for example, β-lactamases inactivating β-lactam antibiotics , modification of the target site that the antibiotic targets so that it can no longer bind properly, efflux pumps, and biofilm production.

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Mycobacterium tuberculosis

Mycobacterium tuberculosis M. tb is a species of pathogenic bacteria in the family Mycobacteriaceae and the causative agent of tuberculosis. First discovered in 1882 by Robert Koch, M. tuberculosis has an unusual, waxy coating on its cell surface primarily due to the presence of mycolic acid.

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Rifampicin

Combination therapy is used to prevent the development of resistance and to shorten the length of treatment. Resistance of Mycobacterium tuberculosis to rifampicin develops quickly when it is used without another antibiotic, with laboratory estimates of resistance rates from 10 −7 to 10 −10 per tuberculosis bacterium per generation.

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Disk diffusion test

Another factor that will influence the size of a zone is the diffusion of the antibiotic within the agar medium and varies based on the molecular configuration of the antibiotic. Once the zone diameter is measured it must be compared to a database of zone standards to determine if the bacterium being studied is susceptible, moderately susceptible, or resistant to the antibiotic in question.

Antibiotic sensitivity testing

Antibiotic sensitivity testing or antibiotic susceptibility testing is the measurement of the susceptibility of bacteria to antibiotics.It is used because bacteria may have resistance to some antibiotics.

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Streptomyces lavendulae

Antibiotic resistance. It has been observed that cultures of S. lavendulae that produce streptothricin are resistant to the effects of this antibiotic. Many studies show the presence of multiple pathways for resistance toward a single antibiotic with the resistance genes located next to the antibiotic biosynthetic genes.

Antimicrobial

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AMR Diagnostic technologies 0 June 20 5 - CEBM

Position Paper on Anti-Microbial Resistance Diagnostics Antimicrobial resistance AMR threatens the effective prevention and were 99.5% and 99%, respectively, and the combined specificity of the assay was 90% Deck et al, 20 2 . diagnostic odds ratio compared with bacteria without Gram stain of 8·7 95% CI:

Antibiotic sensitivity

The last vial in which no bacteria grow contains the antibiotic at the Minimal Inhibiting Concentration. Analysis. Once the MIC is calculated, it can be compared to known values for a given bacterium and antibiotic: e.g. a MIC > 0,06 μg/ml may be interpreted as a penicillin-resistant Streptococcus pneumoniae. Such information may be useful to .

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Broad-spectrum antibiotic

A broad-spectrum antibiotic is an antibiotic that acts on the two major bacterial groups, gram-positive and gram-negative, or any antibiotic that acts against a wide range of disease-causing bacteria. These medications are used when a bacterial infection .

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